Generation of antioxidant mouse models with graded gene expression

The 6th ENGII Conference(Workshop6 2014)——Oxidative stress is implicated in pathogenesis of many diseases and antioxidant therapy is a plausible method for treatment of these diseases. The studies will test our hypothesis that the mice that have low antioxidant levels would be vulnerable to the diseases related to reactive oxygen species (ROS) and these mice would benefit greatly from antioxidant intervention. The hypothesis will be strengthened by exogenous lipoic acid (LA) administration. On the other hand, mice with an enhanced antioxidant reservoir are more resistant to ROS and should retard the development of the diseases.

关键词: 氧化应激 活性氧 抗氧化剂 小鼠模型 遗传方式 The 6th ENGII Conference(Workshop6 2014)

主讲人:Prof. Xianwen Yi 机构:Xinxiang Medical University

时长:0:16:25 年代:2014年